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A-14 (-) Ternatin: A Potent Compound for Obesity Treatment

Technology Application

The compound is useful as a weight control product or supplement for obesity prevention.

Detailed Technology Description

Mice were fed normal diet (group 1; n = 8), high-fat diet (HF) (group 2; n = 8) or HF with 1 (5 mg/kg/day) (group 3; n = 4) for 5 weeks. After this period, the body weights of group 1 and group 2 mice were significantly different, with means of 24.5 and 27.0 g, respectively. Meanwhile, the increase in body weight in group 3 was drastically suppressed (25.8 g) compared to that in group 2. Interestingly, food consumption in group 3 mice (2.2 g/day/head) was similar to that in group 2 mice (2.2 g/day/head). This suggested that the compound suppressed the increase in body weight but did not affect food consumption or appetite.

Supplementary Information

Inventor: UEMURA, Daisuke | SHIMOKAWA, Kenichiro | IWASE, Takaaki | YAMADA, Kaoru
Priority Number: WO2009028248A1
IPC Current: C07K000764 | A61K000864 | A61K003800 | A61P000300 | A61P000304 | A61P004300
Assignee Applicant: National University Corporation Nagoya University
Title: CYCLIC HEPTAPEPTIDE AND USE OF THE SAME | HEPTAPEPTIDE CYCLIQUE ET SON UTILISATION
Usefulness: CYCLIC HEPTAPEPTIDE AND USE OF THE SAME | HEPTAPEPTIDE CYCLIQUE ET SON UTILISATION
Summary: New cyclic heptapeptide useful as an inhibitor for differentiation of adipocyte precursors, an inhibitor of fat deposition in adipocytes, and as pharmaceutical, foodstuff or cosmetic composition (all claimed), which are useful for treating or preventing obesity, and as slimming drug. The foodstuffs include confectionery, supplement, nutritional drink, alcoholic beverage, meat, milk, refreshing drink and grains. The cosmetic includes milky lotion, skin lotion, cream, essence, oil, pack, sheet and washing agent.
Novelty: Novel cyclic heptapeptide, useful as inhibitor for differentiation of adipocyte precursors and inhibitor of fat deposition in adipocytes for treating obesity, and as pharmaceutical, foodstuff or cosmetic composition

Industry

Biomedical

Sub Category

Pharmaceuticals

*Abstract

Nagoya University researchers have focused much attention on wild mushrooms as potential sources of novel bioactive compounds. They found that an extract in ethyl acetate of the mushroom Coriolus versicolor significantly inhibited fat accumulation. Guided by this assay, they isolated the highly N-methylated cyclic heptapeptide (-)-ternatin. The Compound was synthesized from Boc-protected amino acids in solution.

*Principal Investigator

Name: Daisuke Uemura, Ph.D., Emeritus professor at Nagoya University

Department:

Country/Region

USA