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A New Catalyst for producing Amides from Alcohols (Yeda)

A method to produce amides in one step without any unwanted by-products, by coupling of alcohols with amines with the liberation of hydrogen gas, catalyzed by unique ruthenium complexes.

Amides are widely used in the industry (e.g. nylon, Kevlar) and have widespread importance in biochemical and chemical systems (e.g. proteins). Synthesis of amides is mostly based on activated acid derivatives or rearrangement reactions induced by an acid or base, which often produce toxic chemical waste and involve tedious procedures. Therefore, an efficient synthesis that avoids wasteful use of coupling reagents or corrosive acidic and basic media is highly desirable. The current technology allows for the clean production of amides from amines and alcohols.
Technology Benefits
Clean and selective procedure
Environment friendly reaction (no base or acid promoters are required, no carboxylic acid derivatives, such as acid chlorides, are needed)
Amides and molecular hydrogen are produced in high yields and high turnover numbers directly from alcohols in one step
The liberated hydrogen can be used for different applications
Formation of a variety of Amides
Technology Application
Production of amides for various applications (plastic and rubber industry, paper industry, pharmaceutical intermediates, etc.)
Use of the liberated hydrogen (e.g. for the production of ammonia)
Amide formation is a fundamental reaction in chemical synthesis. Amides are commonly formed from the reaction of a carboxylic acid derivative with an amine. Instead of using carboxylic acid derivative, in the present invention the amide motif is generated by direct acylation of amines with alcohols. This is possible through the use of a unique catalyst. This method enables the simple and elegant production of amide polymers and industrially important amides.
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