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Clone, Expression and Application of Schistosoma Japonicum Vaccine Antigen Gene

Summary
目前主要的防治策略是在易感地区大规模化疗及灭螺和健康教育,多年实践证明,反复化疗在疫区能暂时降低发病,但难以阻断传播。因此,发展血吸虫疫苗是综合防治血吸虫病的一项具有战略意义的辅助措施。几十年来,血吸虫疫苗研究经历了从死疫苗、活疫苗、到基因工程疫苗等现代疫苗的一系列探索过程。随着免疫学研究进展,加强了对血吸虫病保护性免疫、发病机制以及肉芽肿形成调节机制的研究,丰富了血吸虫疫苗研究基础知识,尤其近十几年生物化学及分子生物学在寄生虫领域的广泛应用,使得疫苗候选分子的鉴定、基因克隆及表达等方面得到迅速发展。1、提供新的日本血吸虫抗原基因SjE16和SjP50,其分别编码抗原SjE16和SjP50蛋白;2、提供一种制备日本血吸虫抗原SjE16和SjP50蛋白的方法;3、提供一种日本血吸虫防治疫苗,该疫苗分别以日本血吸虫抗原SjE16和SjP50蛋白为目的抗原;4、提供日本血吸虫病防治疫苗在制备预防和治疗日本血吸虫病的药物中的应用
Technology Application
基因工程
Detailed Technology Description
项目目前所处阶段: 研发
有无样品: 无
是否鉴定: 否
Type of Cooperation
技术售让
Coverage Areas
生物技术/制药/医疗
Goods and Services
生物技术工程
Others
寻求高效汽车尾气净化技术及设备,能够适用于搭载稀燃或富燃发动机,以汽油、柴油、天然气或生物燃料为能源的轿车、客车、载货汽车、越野汽车、专用汽车、半挂车、牵引车和自卸汽车等车辆。To seek efficient purification technology and equipment for vehicle exhaust which can be used in cars, buses, trucks, cross-country vehicles, special purpose vehicles, semitrailers, motor tractors and dump trucks driven by lean or rich burn engines fueled gas, diesel, natural gas or bio-fuel.

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