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Method of Using Rhein for Treating Fibrotic Conditions and Tumors

Summary

This invention introduces a new method of using an anthraquinone derivative or known as Rhein, for treating chronic pancreatitis. It is notably that Rhein or extracts from Polygonaceae (rhubarb) is a potential anti-fibrotic agent without giving any adverse effects in the animal study. Most importantly, this invention can suppress pancreatic stellate cell activation for the management of chronic inflammatory, fibrotic and tumorigenic pathologies in the pancreas.

Technology Benefits

• Pure herbal extracts with minimal side effects
• Low toxicity

Technology Application

Used in pharmaceutical product for anti-inflammatory and/ or anti-cancer as well as consumed as a health supplement for specific clinical purpose.

Detailed Technology Description

The present inventionit relates to the method of usageing of an natural anthraquinone derivative, namely 9, 10-Dihyro-4, 5-dihydroxy-9, 10-dioxo-2-anthracenecarboxylic acid, also known as Rhein, as an anti-fibrotic agent. The present invention particularly relates to the suppression of pancreatic stellate cell activation for the management of chronic inflammatoryion, and fibrotic and tumorigenic pathologies in the pancreas of a subject.

Supplementary Information

Patent Number: US8652540B2
Application Number: US13831990A
Inventor: Bian, Zhaoxiang | Tsang, Siu Wai | Lu, Aiping | Xiao, Haitao | Qin, Hongyan | Chan, Albert Sun-Chi | Xu, Hongxi | Chen, Shilin | Yang, Dajian
Priority Date: 4 Jun 2012
Priority Number: US8652540B2
Application Date: 15 Mar 2013
Publication Date: 18 Feb 2014
IPC Current: A01N006500
US Class: 424725
Assignee Applicant: Hong Kong Baptist University
Title: Method of using rhein for treating fibrotic conditions and tumors
Usefulness: Method of using rhein for treating fibrotic conditions and tumors
Summary: For suppressing activation of pancreatic stellate cells and related fibrotic markers in fibrotic conditions or fibrotic related diseases, and for preventing or alleviating or treating pancreatic tumors or pancreatic tumors related diseases in a subject (i.e. a human). The fibrotic conditions comprising pancreatic fibrosis and fibrotic related diseases comprising chronic pancreatitis. The pancreatic tumors or pancreatic tumors related diseases comprising pancreatic ductal adenocarcinoma (claimed).
Novelty: Suppressing activation of pancreatic stellate cells/related fibrotic marker in fibrotic conditions/diseases involves administering composition of extract from Polygonaceae and 9,10-dihyro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid

Industry

Disease Diagnostic/Treatment

Sub Group

Other Disease

Application Date

2013.03.15

Application No.

US 13/831,990

Others

Filed

ID No.

A61/BZ/Rhei/US01

Country/Region

Hong Kong

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