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Methods For The Identification Of Inhibitors Of 5-Aminolevulinate Synthase As Antibiotics

Summary

The Present Inventors Have Discovered That 5-Aminolevulinate Synthase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of 5-Aminolevulinate Synthase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, 5-Aminolevulinate Synthase Can Be Used As A Target For The Identification Of Antibiotics, Preferably Antifungals. Accordingly, The Present Invention Provides Methods For The Identification Of Compounds That Inhibit 5-Aminolevulinate Synthase Expression Or Activity. The Methods Of The Invention Are Useful For The Identification Of Antibiotics, Preferably Antifungals.

Supplementary Information

Inventor: SHUSTER JEFFREY R | TANZER MATTHEW M | HAMER LISBETH | ADACHI KIICHI | DEZWAAN TODD M | LO SZE CHUNG C | MONTENEGRO-CHAMORRO MARIA VICT | FRANK SHERYL A | DARVEAUX BLAISE A | MAHANTY SANJOY K | HEINIGER RYAN W | SKALCHUNES AMY R | PAN HUAQUIN | TARPEY REX
Priority Number: EP1461460A4
IPC Current: C12N001509 | C12N000900 | C12N000910 | C12N000916 | C12N000988 | C12Q000102 | C12Q000118 | C12Q000125 | C12Q000142 | C12Q000148 | C12Q0001527
Assignee Applicant: Icoria Inc
Title: METHODS FOR THE IDENTIFICATION OF INHIBITORS OF ASPARAGINE SYNTHASE, 5-AMINOLEVULINATE SYNTHASE, HISTIDINOL-PHOSPHATASE, 3-ISOPROPYLMALATE AND THREONINE SYNTHASE AS ANTIBIOTICS | VERFAHREN ZUR IDENTIFIZIERUNG VON INHIBITOREN DER ASPARAGINSYNTHASE, 5-AMINO
Usefulness: METHODS FOR THE IDENTIFICATION OF INHIBITORS OF ASPARAGINE SYNTHASE, 5-AMINOLEVULINATE SYNTHASE, HISTIDINOL-PHOSPHATASE, 3-ISOPROPYLMALATE AND THREONINE SYNTHASE AS ANTIBIOTICS | VERFAHREN ZUR IDENTIFIZIERUNG VON INHIBITOREN DER ASPARAGINSYNTHASE, 5-AMINOLÄVULINAT-SYNTHASE, HISTIDINOL-PHOSPHATASE, 3-ISOPROPYLMALAT- UND THREONIN-SYNTHASE ALS ANTIBIOTIKA | METHODES D'IDENTIFICATION D'INHIBITEURS DE L'ASPARAGINE SYNTHASE, DE LA 5-AMINOLEVULINATE SYNTHASE, DE L'HISTIDINOL PHOSPHATASE, DE LA 3-ISOPROPYLMALATE SYNTHASE ET DE LA THREONINE SYNTHASE EN TANT QU'ANTIBIOTIQUES
Novelty: Identifying a candidate antibiotic by detecting e.g. the binding between the test compound and Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase or Threonine synthase

Industry

Biomedical

Sub Category

Bioengineering

Country/Region

Hong Kong