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Methods For The Identification Of Inhibitors Of 3-Isopropylmalate Dehydratase As Antibiotics

The Present Inventors Have Discovered That 3-Isopropylmalate Dehydratase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of 3-Isopropylmalate Dehydratase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, 3-Isopropylmalate Dehydratase Can Be Used As A Target For The Identification Of Antibiotics, Preferably Antifungals. Accordingly, The Present Invention Provides Methods For The Identification Of Compounds That Inhibit 3-Isopropylmalate Dehydratase Expression Or Activity. The Methods Of The Invention Are Useful For The Identification Of Antibiotics, Preferably Antifungals.
Supplementary Information
Inventor: Styczynski, Peter | Ahluwalia, Gurpreet S. | Shander, Douglas
Priority Number: US6060471A
IPC Current: A61K000841 | A61K000849 | A61Q000702
US Class: 514248 | 514334 | 514345 | 514634 | 514635 | 514673
Title: Reduction of hair growth
Usefulness: Reduction of hair growth
Summary: USE The method is used for reducing mammalian hair growth (preferably on the leg, face, arm, armpit or torso) or in a woman suffering from hirsutism or due to androgen stimulated hair growth. Preferably the composition reduces hair growth by at least 40 (especially at least 60) % in the Golden Syrian hamster assay. Depilatory. In the Golden Syrian hamster assay 1,8-diaminooctane (10 μl; 10%) inhibited 74% of hair growth. Hypusine Biosynthetic Pathway-Inhibitor
Novelty: Reducing mammalian hair growth by administering inhibitor of hypusine biosynthetic pathway
Disease Diagnostic/Treatment
Sub Category
Other Disease
Hong Kong

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