Molecular Sieve and Zeolite Microneedles and Preparation Thereof 分子篩和沸石微型針的製造方法
According to a first aspect of the present invention, there is provided a method of making zeolite microneedles comprising a step of preparing polymer template for the needles by a photolithographic process, wherein a layer of photo-sensitive polymeric material is coated on a substrate e.g. silica, glass, quartz, metal, etc. The fabrication of zeolite microneedles involves a precise control of the conditions for front exposure photolithography. To achieve polymeric microneedles with different degree of tapering, exposure time and developing time in the microfabrication process are varied.
According to a second aspect of the present invention, there is provided a method of fabricating hollow zeolite microneedles comprising a step of removal of the polymer needles template from the molecular sieve shell by (i) air calcination method or (ii) ozonation method. According to a third aspect of the present invention, there is provided a method of obtaining either closed-tip or open-tip microneedles Microneedles with either closed or opened tip could be prepared by varying the seeding methods and the growth conditions of zeolites. According to a fourth aspect of present invention, potential applications of microneedles include drug delivery, body fluid extraction and cosmetic purposes.
1. Painless injection
2. No limitations of drug size and structure
3. Good mechanical strength and Biocompatibility
4. Reliable and precise delivery control
- For use in drug delivery , body fluid extraction, cosmetic applications
Patent Number: CN101389374B
Application Number: CN200780006266A
Inventor: Wing Y. Lai | Wenqing Sun | Wai K. Leung | Ling W. Wong | King L. Yeung | Ngar W. Chan
Priority Date: 21 Feb 2006
Priority Number: CN101389374B
Application Date: 16 Feb 2007
Publication Date: 11 Aug 2010
IPC Current: A61M003700
Assignee Applicant: The Hong Kong University of Science & Technology
Title: Molecular sieve and zeolite microneedles and preparation thereof
Usefulness: Molecular sieve and zeolite microneedles and preparation thereof
Summary: Preparation of zeolite microneedles for pen applicator and wristwatch applicator (both claimed).
Novelty: Preparation of zeolite microneedles for pen applicator, involves providing polymer microneedles template, depositing zeolite seeds on polymer microneedles template, and growing zeolite seeds into array of zeolite microneedles
Biomedical
Medical Device
21 Aug 2008
Chinese 200780006266.5
Chinese ZL200780006266.5
TTC.PA.290S
Hong Kong
