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Researchers at UCLA have developed monoclonal antibodies that recognize mouse and human glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 (GPIHBP1).Rat monoclonal antibody, 11A12, against mouse GPIHBP1Mouse monoclonal antibody against human GPIHBP1
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Background
Dietary fats are packaged by the intestines into triglyceride-rich lipoproteins called chylomicrons. The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LPL) along the luminal surface of capillaries, mainly in heart, skeletal muscle, and adipose tissue. GPIHBP1 is a capillary endothelial cell protein that provides a platform for LPL-mediated processing of chylomicrons (Beigneux et al., 2007 [PubMed 17403372]).
