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Mouse model of human respiratory chain disease

Technology Benefits

This invention offered an in vivo mouse model that captures the disease state and has greater relevance to the disorder.This animal line has normal life span, in contrast to the lethal phenotype observed in the homozygous Sco2 KO mice.Mice, compared with other animal models, are relatively economical to maintain, which reduces the developmental costs.

Technology Application

Develop therapeutic approaches to treat human respiratory chain disease.Develop therapeutic targets for aging associated disease including Alzheimer's Disease, Parkinson's Disease and dystonia.Screen drugs and evaluating the efficacy of treatments for those diseases.

Detailed Technology Description

This invention described an in vivo animal model of Sco2 deficiency, which is the first in vivo model that recapitulates the feature of this Sco2 gene-associated human disorder. This invention provides transgenic mice harboring a Sco2 knockout (KO) a...

Country/Region

USA

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