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Cyclodextrins (CD) are cyclic glucose polymers with usually six (alpha), seven (beta) or eight (gamma) glucose residues. They are shaped like doughnuts with a hydrophobic cores and hydrophilic exteriors. Hydrophobic residues from drug molecules can sit inside the cavity and form a complex which may have various uses. Throughout the last few years, interactions of drugs or bioactive components of herbs with cyclodextrins have been systematically explored by us at CityU. The bioavailability of both indomethacin, an antinflammatory drug and andrographolide, a bioactive components purified from the herb Andrographis, have been successfully improved via our molecular complexation technique.
Technology Benefits
contemporary approaches to enhance the dissolution of pharmaceutical preparations have certain problems and do not give the best therapeutic effects
by molecular encapsulating it in a cavity molecule, the solubility and bioavailability of a poorly soluble drug could be improved in addition to being protected from degradation
different methods have been explored for preparing the encapsulated complexes between guest molecules and cavity molecules, but inclusion complexes prepared by means of spray drying at certain conditions give the best results
Technology Application
contemporary approaches to enhance the dissolution of pharmaceutical preparations have certain problems and do not give the best therapeutic effects
by molecular encapsulating it in a cavity molecule, the solubility and bioavailability of a poorly soluble drug could be
molecular encapsulation conditions have been established to produce the micro/nano-size medicinal particulates suitable for use in the manufacture of parenteral or pulmonary pharmaceuticals
the solubility, stability and bioavailability of bioactive components isolated from herbal substances could be significantly enhanced
this technique could also be applied to other industrial products that require a homogenous, stable and yet controlled rate of release of substance for a particular function
