Regradable Polyurethanes That Incoporate Biologically Active Agents for Bone Tissue Engineering Use
- Detailed Technology Description
- None
- *Abstract
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A biodegradable and biocompatible polyurethane composition synthesized by reacting isocyanate groups of at least one multifunctional isocyanate compound with at least one bioactive agent having at least one reactive group --X which is a hydroxyl group (--OH) or an amine group (--NH.sub.2). The polyurethane composition is biodegradable within a living organism to biocompatible degradation products including the bioactive agent. Preferably, the released bioactive agent affects at least one of biological activity or chemical activity in the host organism. A biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is preferably derived from a diurea diol or a diester diol and is preferably biodegradable into biomolecule degradation products or into biomolecule degradation products and a biocompatible diol. Another biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is derived from a diurethane diol and is biodegradable into biomolecule degradation products.
- *Principal Investigator
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Name: Eric Beckman, Professor
Department: Chem/Petroleum Engineering
Name: Jeffrey Hollinger, Professor And Director BTEC
Department: Dent Med-Periodontics/Preventive Dentistry
Name: Jianying Zhang, Research Associate
Department: Med-Orthopedic Surgery
- Country/Region
- USA
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