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A Novel Silica-Coated Superparamagnetic Iron Oxide Nanoparticles with Functional Peripheries for Cell Labeling and Magentic Targetting

Summary

Silica coated super-paramagnetic iron oxide particles with diameters ranging from 4 to 10 nm with different functionalities on the thin silica layer surface are prepared. These nanoparticles with amine functional peripheries increase intracellular cells (including mesenchymal stem cells) labeling efficiency and allow prolonged visibility with techniques including magnetic resonance imaging. These superparamagnetic iron oxide nanoparticles can be used, among others, for in-vivo magnetic resonance imaging cell visualization and magnetic targeted retention of cell for tissue engineering.

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Application No.

07/MED/284/ITF Patent Status: US Patent Pending Licensing Status: Available for licensing

Others

Inventor(s): Professor Yixiang WANG, Department of Diagnostic Radiology and Organ Imaging

Country/Region

Hong Kong

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