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Methods for the Identification of Inhibitors of Alpha-Aminoadipate Reductase and Homocitrate Synthase as Antibiotics

总结

The present inventors have discovered that alpha-Aminoadipate Reductase and Homocitrate Synthase are each essential for fungal pathogenicity. Specifically, the inhibition of alpha-Aminoadipate Reductase or Homocitrate Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, alpha-Aminoadipate Reductase or Homocitrate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit alpha-Aminoadipate Reductase or Homocitrate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.; The present inventors have discovered that [alpha]-Aminoadipate Reductase and Homocitrate Synthase are each essential for fungal pathogenicity. Specifically, the inhibition of [alpha]-Aminoadipate Reductase or Homocitrate Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, [alpha]-Aminoadipate Reductase or Homocitrate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit [alpha]-Aminoadipate Reductase or Homocitrate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

附加资料

Patent Number: AU2002365038A8
Application Number: AU2002365038A
Inventor: DARVEAUX BLAISE | LO SZE-CHUNG | TANZER MATTHEW | PAN HUAQUIN | DEZWAAN TODD | SHUSTER JEFFREY | TARPEY REX | HEINIGER RYAN | FRANK SHERYL | MAHANTY SANJOY | HAMER LISBETH | MONTENEGRO-CHAMORRO MARIA VICT | ADACHI KIICHI | SKALCHUNES AMY
Priority Date: 9 Nov 2001
Priority Number: AU2002365038A8
Application Date: 12 Nov 2002
Publication Date: 10 Jun 2003
IPC Current: G01N003350 | C12N000902 | C12N000910 | C12N000988 | C12N001509 | C12Q000102 | C12Q000118 | C12Q000126 | C12Q0001527 | C12Q000168 | G01N003315
Assignee Applicant: Paradigm Genetics Inc
Title: Methods for the identification of inhibitors of alpha-aminoadipate reductase and homocitrate synthase as antibiotics
Usefulness: Methods for the identification of inhibitors of alpha-aminoadipate reductase and homocitrate synthase as antibiotics
Summary: Identifying a test compound as a candidate for an antibiotic, preferably antifungal (claimed).

主要类别

农业

细分类别

植物

国家/地区

香港