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Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer
詳細技術說明
Dr. Salem and his colleagues at the University of Iowa have developedthe optimal nanoparticle formulation to enhance therapeutic efficacy in tumorswith mutant p53 through a comprehensive analysis of release profiles, cellularuptake, and cell viability. In a xenograft model of USC, this novel therapyresulted in marked inhibition of tumor progression and extended survival. Thisnovel formulation promoted synthetic lethality, specifically in USC withloss-of-function p53 mutation, enhancing the effectiveness of EC treatment withPTX.
國家/地區
美國
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