A Novel Target for the Neutralization of Cancer Stem Cells in Glioblastoma
May increase efficacy of GBM treatmentsNon-toxic to healthy cells; reduces comorbiditiesTargets slow-dividing stem cells as opposed to rapid-dividing cells (i.e. chemotherapies)
· Targeting cancer stem cells to increase efficacy of GBM treatment
Glioblastoma (GBM) is the most common, aggressive, and lethal primary brain tumor in adults. Currently, only four drugs are approved for GBM treatment. The current standard of care drug for GBM, Temozolomide, provides a limited survival advantage of less than 3 months, even when with combined surgical and radiation therapies. Furthermore, standard therapy is highly toxic to healthy cells. In GBM, cancer stem cells are associated with chemotherapy resistance and tumor recurrence. The increased proliferation of the cancer stem cell population is a prognostic marker for disease progression and poor clinical outcome; however, few therapeutic strategies target cancer stem cell self-renewal. UCI scientists have discovered a novel mechanism that can be exploited to regulate cancer stem maintenance and renewal to treat GBM, and may provide a promising approach to increase the overall efficacy of GBM treatment modalities.
State Of Development · Ongoing and future plans include: o Development of a neutralizing antibody to target cancer stem cell renewal in vivo o Test efficacy of combined neutralizing antibody with Temozolomide o Evaluation of therapeutic candidate in vitro and in vivo Tech ID/UC Case 29238/2017-888-0 Related Cases 2017-888-0
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