Accelerated Degradation of Pharmaceuticals and Related Chemical Processes
Researchers at Purdue University have developed a new forced degradation method. Using Leidenfrost droplets to accelerate forced degradation and nanospray mass spectrometry (MS) to characterize the reaction products, the reaction/analysis sequence provided results within minutes, i.e., five minutes, versus taking up to a week to complete. The FDA requires forced degradation for licensing, which causes a bottleneck in pharmaceutical production. An accelerated forced degradation method could help eliminate this bottleneck.
FasterMore efficientReliablePotential to speed up FDA licensing process
Pharmaceutical industryDrug development
R. Graham CooksPurdue ChemistryAston Labs
United States
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美國
