Cancer Immunotherapy Using Nanoparticles and the Generation of Functional Dendritic Cells
Thetechnology includes novel nanoparticles which have a mitochondrial targetingmoiety and a photosensitizer configured to produce a reactive oxygen specieswhen exposed to light of an appropriate wavelength, as well as a method ofusing these particles. Dysfunction of a host’s immune system is one of themajor mechanisms by which tumors evade immune surveillance. Tumors employ strategies to successfullyevade the host immune system, and these strategies may target immune antitumoreffector cells. Dysfunction andapoptosis of these immune antitumor effector cells in the host creates animmune imbalance that cannot be corrected by immunotherapies aimed only atactivation of anti-tumor immune response. Reversal of existing immune dysfunction and normalization of lymphocytehomeostasis in patients with cancer may play an important role in future cancerimmunotherapies.
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