Methods for Producing Neocartilage with Functional Potential
Efficacious production of neocartilage Formation of functional human neocartilage similar to native cartilagePotential supplement to TCL treatment to enhance functional propertiesNovel tissue engineering techniques
· Neotissue production (e.g., neocartilage) · Tissue-engineered cartilage-like tissue (TCL) treatment · Tissue engineering applications
UCI scientists have discovered methods and compositions for producing highly expanded cells with an ability to form neocartilage. The method of cell expansion entails culturing the cells from cadaveric tissue in a cocktail of growth factors and differentiating agents, and culturing in 3-D the expanded cells for redifferentiation in a redifferentiation cocktail. The resulting engineered cells have functional properties comparable to native cartilage and the potential to produce neocartilage. Notably, the invention enables a large quantity of engineered cartilage implants to be produced from a few cells.
State Of Development In vitro evaluation of native and engineered tissues using cadaveric cartilage Assessed biomechanical and biochemical properties Tech ID/UC Case 29129/2017-960-0 Related Cases 2017-960-0
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