Novel Triazole Bisphosphonate Geranylgeranyl Diphosphate Synthase Inhibitors
Dr.Wiemer’s lab has developed a novel class of triazole bisphosphonategeranylgeranyl diphosphate synthase (GGDPS) inhibitors that can be used assingle isomers. These inhibitors are water-soluble and can be readily synthesized.These compounds target an enzyme in isoprenoid biosynthesis that allows cellsto export proteins. Protein export is important in living organisms; however, manydiseases are characterized by cells that overreact to protein synthesis andexport. These novel compounds can inhibit the export of proteins from thediseased cells, resulting in programmed cell death. Therefore, the inhibitorsrepresent a novel therapeutic strategy for the treatment of various diseases,including multiple myeloma and other types of cancers.
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