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Therapy for Restoration of Impaired Insulin Secretion

詳細技術說明

This invention describes the use of ebselen in the treatment for diabetes and hypoglycemia, which has been shown to improve glucose-stimulated insulin secretion (GSIS) in islets.

其他

Patent application No. US 2015/0297564
X. Wang, J-W Yun, and X. G. Lei. (2014). Glutathione peroxidase mimic ebselen improves glucose-stimulated insulinsecretion in murine islets. Antioxidants& Redox Signaling. Vol.20(2): 191-203. DOI:10.1089/ars.2013.5361
X.Wang, et al. (2011). Knockouts of SOD1 and GPX1 Exert Different Impactson Murine Islet Function and Pancreatic Integrity. Antioxidants & Redox Signaling. Vol.14(3):391-401. DOI: 10.1089/ars.2010.3302.

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