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Use of BDNF to Treat Microvascular Disease

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Donovan MJ et al (2000) Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development. (21):4531-40.
Kermani P et al (2005) Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors J Clin Invest. 115:653-663.
Kermani P, Hempstead B. (2007) Brain-derived neurotrophic factor: a newly described mediator of angiogenesis. Trends Cardiovasc Med. 2007 May;17(4):140-3. Review.
Kim H et al (2004) Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells. J Biol Chem 279(32):33538-46.
Kraemer R, Hempstead BL. (2003) Neurotrophins: novel mediators of angiogenesis. Front Biosci. 8:s1181-6. Review.
Shmelkov SV et al. (2005) Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue. Circulation 111(9):1175-83.

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