Compounds Useful Against Acute Neurogenic Inflammation
The bis-heterocyclic compounds represent a basis for the development of novel therapeutics for the control of neurogenic pain and inflammation.
The bis-heterocyclic compounds may be useful in the treatment of: Chronic pain, migraines, and arthritis. Inflammatory conditions that involve a neurogenic pain-producing component, such as certain metastic carcinomas or inflammation of the blood vessels. Skin conditions, including radiation irritation and burns, chemical burns, rhinitis, thermal burns, and reddening of the skin. Allergic responses.
Researchers at the University of California have discovered that bis-heterocyclic compounds are highly effective in inhibiting neurogenic inflammation. The compounds, pharmaceutical preparations including the compounds, and methods for administering the compounds are available.
Patent Number: US5955462A
Application Number: US1997961475A
Inventor: Jacobs, Robert S. | Pomponi, Shirley A. | Gunasekera, Sarath P. | Wright, Amy E.
Priority Date: 31 Oct 1996
Priority Number: US5955462A
Application Date: 31 Oct 1997
Publication Date: 21 Sep 1999
IPC Current: C07D040314 | A61K003100 | A61K00314025 | A61K00314045 | A61K00314178 | A61K0031496 | A61K0031497 | A61P001702 | A61P002500 | A61P002900 | A61P003708 | C07D020914
US Class: 51425409 | 514254 | 51425505 | 514397 | 514402 | 514497
Assignee Applicant: Harbor Branch Oceanographic Institution Inc.,Fort Pierce | The Regents of the Univ. of California,Oakland
Title: Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
Usefulness: Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
Summary: USE The method is for treating pain particularly caused by migraine, rhinitis and thermal-, radiation- and chemical- induced pain, chemical-, radiation- and thermal- burns and allergic response and for promoting wound healing. The dosage of (I) is 0.01-20 mg/kg intravenously, by aerosol or by intranasal instillation, 0.01-100 mg/kg intraperitoneally, subcutaneously or intramuscularly or 0.01-200 (preferably 1-100) mg/kg.
Novelty: Inhibiting or controlling neurogenic inflammation using bis-heterocyclic compound, used for treating chemical, radiation and thermal burns and allergic response
化工/材料
化工/材料應用
5955462
Tech ID/UC Case 10092/1997-118-0 Related Cases 1997-118-0
美國
