On-Demand Release of Guest Molecules by Using Mesoporous Silica Nanoparticles Equipped with Nanoimpellers

Higher efficacy achieved by specific targetingPrecise releaseSpatial and temporal external control

Targeted therapyOn-demand release of:anti-cancer drugs (cancer therapy)anti-microbial drugs (i.e. dental treatment)anti-viral drugs (i.e. agriculture)

UCLA researchers have successfully developed a nanoimpellar based nanoparticle to transport molecules into living cells and have demonstrated both temporal and site-specific release under photo-activation. These nanoparticles are avidly taken up in vitro and have demonstrated specific photo-controlled release of both fluorescent dyes and apoptosis inducing cancer drugs in cell lines of both pancreatic and colon cancer. This invention represents a novel approach for external control of drug release, and has very strong potential in a number of applications.

Patent Number: US20100284924A1
Application Number: US2010812359A
Inventor: Zink, Jeffrey I. | Tamanoi, Fuyuhiko | Choi, Eunshil | Angelos, Sarah | Kabehie, Sanaz | Nel, Andre | Lu, Jie
Priority Date: 23 Jan 2008
Priority Number: US20100284924A1
Application Date: 9 Jul 2010
Publication Date: 11 Nov 2010
IPC Current: A61K000914 | A61K000802 | A61K004900 | A61P003500 | A61P004300 | A61Q009000 | B32B000500
US Class: 4240091 | 424401 | 424489 | 428402
Assignee Applicant: The Regents of the University of California
Title: NANO-DEVICES HAVING IMPELLERS FOR CAPTURE AND RELEASE OF MOLECULES
Usefulness: NANO-DEVICES HAVING IMPELLERS FOR CAPTURE AND RELEASE OF MOLECULES
Summary: Nano-device for capturing and release of molecules in fluidics and drug delivery, and used for biological and biomedical applications.
Novelty: Nano-device for capturing and release of molecules in e.g. fluidics, has impeller that is attached to containment vessel for loading, unloading or containing molecules in containment vessel

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Background

With targeted drug delivery, the overall goal is to restrict treatment to a specific subset of cells. This approach would both reduce off target cytotoxicity and vastly enhance the efficacy of drug treatment. Towards this end, a number of approaches have been developed with varied success. Recently, nanoparticles have shown great promise as drug delivery vehicles due to their flexibility, scalability, and ease of use. Through use of a light-activated, mesoporous, silica nanoparticle, researchers at UCLA have developed an innovative trap and release scheme that will allow for precise control of drug delivery. The use of a photo-controlled agent for targeted drug delivery has not been demonstrated up to this point.

Related Materials

Light-Activated Nanoimpeller-Controlled Drug Release in Cancer Cells

Additional Technologies by these Inventors

• Novel Non-Peptidomimetic Prenyl Transferase Inhibitors

Tech ID/UC Case

21563/2008-232-0

Related Cases

2008-232-0

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