Intelligent Nanomedicine Integrating Diagnosis and Therapy
Cytotoxicity of healthy cells can be reduced. The nanomedicine can be easily diversified. It can be directly applied to many current therapies.
The technology can be used to selectively target drugs to their intended sites of action.
UCLA researchers have invented an intelligent nanomedicine that is only activated in sick cells due to its dual integration of diagnostic and therapeutic functions. The diagnosis is continuously performed through the recognition of biomarkers for a specific disease. The nanomedicine changes its confirmation when the diagnostic result changes, either activating or deactivating the drug. Thus, the nanomedicine can intelligently adjust its dosage according to the amount of biomarker present.
Patent Number: US8257918B2
Application Number: US2006631738A
Inventor: Li, Na | Tan, Winny
Priority Date: 7 Jul 2004
Priority Number: US8257918B2
Application Date: 3 Dec 2007
Publication Date: 4 Sep 2012
IPC Current: C12Q000168 | C07H002102 | C07H002104
US Class: 4350061 | 435006 | 5360231 | 53602431 | 53602433 | 5360245
Assignee Applicant: The Regents of the University of California
Title: Intelligent nanomedicine integrating diagnosis and therapy
Usefulness: Intelligent nanomedicine integrating diagnosis and therapy
Summary: The methods and compounds are useful for treating cancer (claimed).
Novelty: Controlling the activity of a biologically active compound, useful for treating cancer, comprises providing a hairpin-forming oligonucleotide capable of existing in either a hairpin configuration, or an open configuration
診斷/治療
癌症/腫瘤
Background With the rapid advances of modern pharmacology, effective drugs have been discovered for many diseases; however, most of those drugs have undesirable side effects due to their inability to distinguish between diseased and healthy cells. For instance, chemotherapy that is commonly used for treatment of cancer does not only target the cancer cells, but also damages healthy cells. Additional Technologies by these Inventors Tech ID/UC Case 20184/2004-675-0 Related Cases 2004-675-0
美國
