RNA-based Ovarian Cancer Diagnostic
Advantages of this approach include the ability to: detect ovarian cancer in the asymptomatic phase of the disease;use tissue samples that are routinely collected in a gynecologic exam; anddetect at high sensitivity (a few tumor cells).
Early detection of ovarian cancer
UC Inventors have discovered a number of mRNA transcripts that are selectively expressed in ovarian tumors and may be used to detect the presence of an ovarian tumor in a Pap smear and/or endometrial biopsy.
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State Of Development A number of ovarian tumor-specific transcripts have been identified and relevant primers developed. Work is continuing to identify additional tumor-specific transcripts and to optimize primers for detection in the relevant tissues. Intellectual Property Info Worldwide rights available; Pending patents available under confidentiality. Related Materials Cramer et al., Ovarian cancer biomarker performance in prostate, lung, colorectral, and ovarian cancer screening trial specimens, 2011; Cancer Prev Res (Phila), 4(3):365-74. Tech ID/UC Case 24303/2014-349-0 Related Cases 2014-349-0
Zhu et. al., A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer, 2011, Cancer Prev Res (Phila), 4(3):375-83
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