Optical Switching and Sorting of Biological Samples and Microparticles in a Micro-Fluidic Device
The invention provides methods and devices in which microscopic particles or cells within a fluid flowing in microfluidic channels are selectively manipulated, normally by being pushed with optical pressure forces at branching junctions in the channels so as to enter into selected downstream branches, thereby realizing particle switching and sorting. Transport of the particles thus transpires by microfluidics while manipulation in the manner of optical tweezers arises either from pushing due to optical scattering force, or from pulling due to an attractive optical gradient force. Whether pushed or pulled, the particles within the flowing fluid may be optically sensed, and highly-parallel, low-cost, cell- and particle-analysis devices thus may be efficiently realized, including as integrated on bio-chips.
Patent Number: US6778724B2
Application Number: US2001998012A
Inventor: Wang, Mark | Ata, Erhan Polatkon | Esener, Sadik C.
Priority Date: 28 Nov 2000
Priority Number: US6778724B2
Application Date: 28 Nov 2001
Publication Date: 17 Aug 2004
IPC Current: G21K000100 | H05H000304
US Class: 385016 | 422504 | 428188 | 422100
Assignee Applicant: The Regents of the University of California
Title: Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
Usefulness: Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
Summary: In optical tweezer (claimed) for flow cytometry, biological microoptical electromechanical system, microfluidic sorting device, biotech research and therapeutic medicine application.
Novelty: Biological particle spatially switching method in optical tweezer, comprises radiating laser beam into microfluid channels, to move particle to selected specific destination channel
生物醫學
醫療裝置
6778724
Intellectual Property Info The invention has U.S. patent number 6,778,724, Optical Switching and Sorting of Biological Samples and Microparticles Transported in a Micro-Fluidic Device, Including Integrated Bio-Chip Devices. See also U.S. patent number 7,068,874 Microfluidic Sorting Device and corresponding Australian patent AU 2002230530, which are available for licensing. Tech ID/UC Case 21970/2001-051-0 Related Cases 2001-051-0
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