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Smart Materials Capable of Programmed Shape Change

技術應用

The invention has a wide range of biomedical and device applications including phase-change triggered drug delivery, morphology-controlled pharmacokinetics, phase-change activated MRI contrast agents, and biotemplating of materials for nanoelectronics.

詳細技術說明

UC San Diego researchers have developed soft nanoparticle materials that exhibit reversible, stimuli-responsive changes in morphology. In its primary embodiment, the invention leverages the utility of DNA as an informational molecule to design nanoparticles that undergo reversible morphological changes in a DNA-encoded fashion. Utilizing the sequence selective recognition properties of DNA, and its performance as a substrate for selective enzymatic cleavage, the amphiphilicity of a range of surfactants is programmed and tuned. This approach provides unprecedented programmability and reversible control over the morphology of nanoscale objects and allows user-defined selection of particle shapes and sizes. Control over these materials and their utility in detection, reversible uptake/release, and as soft material templates have been demonstrated. Another inventive aspect provides peptide-based enzymatic responsive systems.

附加資料

Patent Number: US20120149843A1
Application Number: US13363645A
Inventor: Chien, Miao-Ping | Gianneschi, Nathan C.
Priority Date: 3 Aug 2009
Priority Number: US20120149843A1
Application Date: 1 Feb 2012
Publication Date: 14 Jun 2012
IPC Current: C08F029112 | A61K000802 | A61K000970 | B05D000714 | C08F029900 | C12P001934 | C12Q000168 | B82Y000500 | B82Y004000
US Class: 5250541 | 424401 | 424443 | 427216 | 4350061 | 4350911 | 5250542 | 977788 | 977890 | 977906 | 977915
Assignee Applicant: The Regents of the University of California
Title: NANOFIBERS AND MORPHOLOGY SHIFTING MICELLES
Usefulness: NANOFIBERS AND MORPHOLOGY SHIFTING MICELLES
Summary: For targeted cancer treatment; and in a variety of chemical, pharmaceutical and electronic applications.
Novelty: Micelle useful for targeted cancer treatment, comprises aggregated brush copolymers having hydrophilic portion and hydrophobic portion