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Enzyme-Logic Biosensing for Rapid Diagnostics

詳細技術說明

UC San Diego researchers have developed biochemical logic methods and systems for rapid, high-fidelity diagnostics. The invention employs multiple markers as inputs to biochemical logic gates (e.g., “AND” and “XOR”) to trigger a cascade of enzymatic reactions and thus compute a final, digital answer regarding a patient’s physiological condition (“YES” or “NO”). Further, in the invention, biochemical signals logically processed by enzymes can be coupled with other sensing elements, e.g., electronic transducers operating as multi-signal responsive biosensors, or nano-structured signal-responsive materials operating as chemically triggered actuators. In one embodiment, the invention uses biomarkers for brain injury, trauma, shock, fatigue, etc., as inputs for physiological information biocomputing to facilitate rapid and accurate analysis, decision-making, and therapeutic intervention in the case of injured soldiers or accident victims. In another embodiment, the invention provides a sensor system for on-the-spot monitoring of multiple cardiac markers to allow fast and reliable detection of heart-attack symptoms, particularly identifying myocardial injury, independently of chest discomfort or other common warning signs. Proof of concept has been achieved for the invention’s enzyme-reaction processing of biochemical signals at their physiologically relevant concentrations. The invention also provides for a drug-delivery feedback-loop coupled with the diagnostic signal output.

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