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Assay for Small Molecules and Defined Factors to Trigger Renewal of Cardiac Progenitors

詳細技術說明

Scientists at UC San Diego have discovered a high-throughput screening assay for identifying a detectably labeled small molecule that modulates cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also provided are methods of stimulating maturation of cardiac progenitor cells using a GSK-3P inhibitor.

附加資料

Patent Number: US8323909B2
Application Number: US2010770597A
Inventor: Evans, Sylvia | Chen, Ju | Lin, Lizhu | Chien, Ken | Qyang, Yibing | Moretti, Alessandra | Laugwitz, Karl
Priority Date: 2 Feb 2004
Priority Number: US8323909B2
Application Date: 29 Apr 2010
Publication Date: 4 Dec 2012
IPC Current: C12N000500 | G01N003353
US Class: 4350071 | 435375 | 435377
Assignee Applicant: The Regents of the University of California
Title: Methods of identifying small molecules for renewals, survival and migration of cardiac progenitors
Usefulness: Methods of identifying small molecules for renewals, survival and migration of cardiac progenitors
Summary: The assay and methods are useful for identifying a small molecule, which affects or regulates cardiogenesis, high-throughput screening assay, stimulating maturation of cardiac progenitor cells, and for generating an Isl1 lineage-traced cell.
Novelty: Identifying small molecule regulating cardiogenesis by determining islet 1 transcription factor expression in labeled cardiac progenitor cells isolated from transgenic non-human animal having tamoxifen-dependent Cre-recombinase