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pH-"Tunable" Nano-Particle Drug Delivery System

技術應用

These features should prove extremely relevant for clinical applications, from cancer to ophthalmology, where increased efficacy and reduce drug toxicity can enhance the therapeutic profile and/or extend patient life for promising and useful drugs.

詳細技術說明

A new class of linkers has been developed to address these limitations. These linkers: Undergo controlled hydrolysis at physiological temperature and in mild aqueous, acidic environments.Can be tuned to hydrolyze with half-lives from thirty minutes to greater than nine months. Accommodate a wide range of biocompatible drug carriers. Flexibly conjugate to a wide variety of drugs (via alcohol, amine, or imidazole).

附加資料

Patent Number: US8575359B2
Application Number: US2008295858A
Inventor: Yang, Jerry | Kong, Seong Deok | Luong, Alice | Howell, Stephen
Priority Date: 4 Apr 2006
Priority Number: US8575359B2
Application Date: 20 Sep 2010
Publication Date: 5 Nov 2013
IPC Current: C07D023300 | C07D023302 | C07D023354 | C07D023360 | C07H001524
US Class: 5483001 | 5360064 | 5483415
Assignee Applicant: The Regents of the University of California
Title: Acid-sensitive linkers for drug delivery
Usefulness: Acid-sensitive linkers for drug delivery
Summary: As acid-sensitive linkers for delivering drugs useful for treating cancer and for inhibiting cell proliferation and growth of cancer cells.
Novelty: New imidazole derivatives, as acid-sensitive linkers for delivering drugs useful for treating cancer and for inhibiting cell proliferation and growth of cancer cells