Method For Preparation Of Micellar Hybrid Nanoparticles For Combined Therapeutic And Diagnostic Medical Applications
In-vivo stability allows for prolonged integrity in systemic circulation. Micellar structure allows delivery of a broad array of payloads, including, magnetic particles, quantum dots, or a therapeutic agent. Reduced cytotoxicity of both hydrophobic drugs and nanoparticle itself. Enables co-delivery of therapeutic agents and diagnostic agents that enable imaging.
Medical imaging Cancer diagnostics and therapeutics Diagnostic and therapeutics for various diseases Vaccines
This invention provides both the composition and a novel method for creating micellar hybrid nanoparticles that exhibit substantial in vivo circulation times, allowing them to contain a diverse payload for periods of time sufficient for delivery and subsequent release to a desired tissue. In addition, this technology readily facilitates the simultaneous targeted delivery of both therapeutic and imaging agents to diseased tissue in vitro or in vivo.
Patent Number: US20120059240A1
Application Number: US13219906A
Inventor: Sailor, Michael J. | Bhatia, Sangeeta N. | Park, Ji-Ho | Von Maltzahn, Geoffrey A.
Priority Date: 24 Jun 2008
Priority Number: US20120059240A1
Application Date: 29 Aug 2011
Publication Date: 8 Mar 2012
IPC Current: A61B0005055 | A61K000914 | A61K0031704 | A61K004900 | A61K004918 | A61N000210 | A61P003500 | C12Q000102 | C12Q000168 | G01N0033566 | B82Y000500 | B82Y002500 | B82Y004000
US Class: 600409 | 4240091 | 4240093 | 424490 | 4350061 | 4350071 | 435029 | 514034 | 600012 | 977773 | 977774 | 977838 | 977915
Assignee Applicant: Massachusetts Institute of Technologymbridge | The Regents of the University of California
Title: METHOD FOR PREPARATION OF MICELLAR HYBRID NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS AND COMPOSITIONS THEREOF
Usefulness: METHOD FOR PREPARATION OF MICELLAR HYBRID NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS AND COMPOSITIONS THEREOF
Summary: The compositions are useful for treating or diagnosing disease or disorder in subject (claimed). Disease or disorder includes cancer, neoplasm and proliferative disorders.
Novelty: New micelle compositions encapsulating different nanostructures at least two of nanostructures having different excitation/emission spectrums or detectable signals, useful for treating or diagnosing disease, e.g. cancer, in subject
診斷/治療
癌症/腫瘤
State Of Development This technology is offered exclusively or nonexclusively for U.S. and/or worldwide territories. A commercial sponsor for potential future research is sought. This technology has been used in vitro and in vivo to deliver an anti-cancer agent and two types of nanoparticles that aid in fluorescence and magnetic resonance imaging to diseased tissue (see reference below). Related Materials Tech ID/UC Case 19171/2008-313-0 Related Cases 2008-313-0
美國
