Her2/neu Vaccine Protects Against Tumor Growth
University of California, Irvine researchers have developed a recombinant polynucleotide encoding Her2/neu target antigen. This recombinant polynucleotide contains two regions of the human Her2/neu molecule which demonstrated the lowest degree of homology with other known normal human proteins as the putative target antigen sequence for a genetic vaccination strategy. This target sequence was chosen to minimize any potential cross reactive auto-immune response and to maximize specificity of the elicited immune response. These portions of human Her2/neu contain some of the previously identified T cell epitopes. Because this sequence is predominantly intracellular and represents a truncated or partial protein sequence, the protein is anticipated to be rapidly degraded and presented in the context of MHC class I and thus be available for CTL recognition.
Patent Number: US7446185B2
Application Number: US2003484067A
Inventor: Nelson, Edward L.
Priority Date: 18 Jul 2001
Priority Number: US7446185B2
Application Date: 19 May 2004
Publication Date: 4 Nov 2008
IPC Current: C07H002104 | C07K001400 | C07K001447 | C12N000510 | C12N001511 | C12N001563 | A61K003800 | A61K003900
US Class: 5360231 | 4353201 | 435325 | 530350
Assignee Applicant: The Regents of the University of California
Title: Her2/neu target antigen and use of same to stimulate an immune response
Usefulness: Her2/neu target antigen and use of same to stimulate an immune response
Summary: The polynucleotide encoding a Her2/neu target antigen is useful for stimulating immunoeffector cells or an immune response in a subject against cancer cells expressing Her2/neu. The encoded Her2/neu target antigen polypeptide is useful as a tag to detect or isolate the fusion protein containing the Her2/neu target an immune response stimulated by the Her2/neu target antigen. The Her2/neu target antigen polynucleotides and polypeptides are useful in genetic or polypeptide vaccination strategies.
Novelty: New Her2/neu target antigens and polynucleotides encoding them, useful for stimulating immunoeffector cells or an immune response in a subject against cancer cells expressing Her2/neu, and for vaccination strategies
診斷/治療
癌症/腫瘤
7446185
Tech ID/UC Case 18903/2001-288-0 Related Cases 2001-288-0
美國
