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Live Imaging of Corneal Lymphatic Vessels

技術優勢

Identifies lymphatic vessels in live and intact corneas, which can be induced by a variety of pathological stimulations, such as inflammation, cancers and tumors, infection, trauma, transplantation, or chemical burn Lymphatic vessels can be labeled in different colors Provides live molecular level videos and detailed 2-4 dimensional lymphatic vessels pictures Over-the-course longitudinal observation of dynamic lymphatic processes (from formation to maturation and regression) in the same tissue and subject Detects lymphatic interaction with other components in the local environments, such as cells, blood vessels, and nerves Non-invasive local method; dye is bio-degradable and harmless to human health Readily applicable to patient setting

技術應用

Research systems and apparatus for use with a broad spectrum of molecular and cellular mechanisms underlying lymphatic processes from formation to maturation and regression in laboratory and in clinics Research systems and apparatus to assess and diagnose lymphatic vessels of the cornea in diseases, and provide guidelines for therapeutic intervention of lymphatic processes, whether at the early, middle, or late stages, or before and after a pharmaceutical intervention. Lymphatic specific drug delivery tool

詳細技術說明

None

附加資料

Patent Number: US20140121512A1
Application Number: US14069116A
Inventor: Chen, Lu | Yuen, Don
Priority Date: 31 Oct 2012
Priority Number: US20140121512A1
Application Date: 31 Oct 2013
Publication Date: 1 May 2014
IPC Current: A61B000500 | A61B001900
US Class: 600431
Assignee Applicant: The Regents of the University of California
Title: IN VIVO VISUALIZATION OF LYMPHATIC TISSUE
Usefulness: IN VIVO VISUALIZATION OF LYMPHATIC TISSUE
Summary: Method for visualizing lymphatic tissue in an ocular region i.e. cornea, of a living subject e.g. mammal (all claimed) such as mouse and human, in research and therapeutic applications.
Novelty: Method for visualizing lymphatic tissue in ocular region of cornea of e.g. mouse in research and therapeutic applications, involves contacting ocular region with detectably-labeled lymphatic tissue-specific dye, and detecting dye