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Synthetic transcriptional control elements

技術優勢

Easy to designOperate on entire operonsHighly amenable to development and modificationOffer a broader dynamic range for expression of the regulated nucleic acid of interest than with cis-regulators of translation aloneAllow for precise regulation of the level of expression of the nucleic acid of interest

技術應用

Gene expression control systems for bioengineeringCustomizable regulators for gene expression

詳細技術說明

None

附加資料

Inventor: QI, Lei S. | LIU, Chang | ARKIN, Adam P.
Priority Number: WO2013049330A1
IPC Current: C07H002102 | C12N001500
Assignee Applicant: The Regents of the University of California
Title: SYNTHETIC TRANSCRIPTIONAL CONTROL ELEMENTS AND METHODS OF GENERATING AND USING SUCH ELEMENTS | ÉLÉMENTS SYNTHÉTIQUES DE CONTRÔLE TRANSCRIPTIONNEL ET MÉTHODES DE GÉNÉRATION ET D'UTILISATION DE CES ÉLÉMENTS
Usefulness: SYNTHETIC TRANSCRIPTIONAL CONTROL ELEMENTS AND METHODS OF GENERATING AND USING SUCH ELEMENTS | ÉLÉMENTS SYNTHÉTIQUES DE CONTRÔLE TRANSCRIPTIONNEL ET MÉTHODES DE GÉNÉRATION ET D'UTILISATION DE CES ÉLÉMENTS
Summary: The nucleic acid construct, cell, method or kit is useful for converting cis-regulator of translation into synthetic TCRT. The composition and method are also useful for synthetic gene regulation. The synthetic TCRT is used to regulate the expression of a downstream nucleic acid sequence of interest.
Novelty: New nucleic acid construct useful for converting cis-regulator of translation into synthetic translation-coupled regulator of transcription, comprises synthetic translation-coupled regulator of transcription