Glycosylated Polyamines As Anticancer, And Cancer Chemotherapeutic Compounds
In screening assays conducted by the Natinal Cancer Institute, one of the compounds has been shown to be more potent than tamoxifen in inhibiting growth of certain cancer cell lines.A detailed drug development plan is available for this technology.Stereochemically pure product is easily isolated and crystallized as a hydrochloride salt.
These compounds can be used as anticancer, and chemotherapeutic agents against breast, ovarian, and a variety of other cancers. Based on the crystallographic studies of the structure of one of the compounds, these compounds are predicted to interact with the estrogen receptor, and thus can be used to modulate estrogen receptor activity in a variety of conditions or diseases involving estrogen-mediatedactivities including: (1) prevention or delay of the onset of breast cancer,(2) treatment or prevention of osteoporosis, (3) treatment, prevention or delaying of the onset of uterine disorders, (4) as a modulator of ovulation for purposes of fertility treatment and/or contaception, and (5) for reducing cardiovascular disease in postmenupausal women. Can be used as ligands in preparing metal complexes for developing analytical methodology.
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Patent Number: US6420344B1
Application Number: US2000524729A
Inventor: Leary, Julie A. | Gaucher, Sara P. | Pedersen, Steven F.
Priority Date: 16 Mar 1999
Priority Number: US6420344B1
Application Date: 14 Mar 2000
Publication Date: 16 Jul 2002
IPC Current: C07H001512 | C07H001526
US Class: 514042 | 514053 | 5360172 | 5360179 | 5360291
Assignee Applicant: The Regents of the University of California
Title: Glycosylated polyamines
Usefulness: Glycosylated polyamines
Summary: Compounds (I) are useful for treating or preventing cancer such as leukemia, non-small-cell lung cancer, small-cell lung cancer, colon cancer, a cancer of the central nervous system, melanoma, ovarian cancer, breast cancer, renal cancer and prostate cancer.
Novelty: Novel glycosylated polyamines, useful for treating cancer
診斷/治療
癌症/腫瘤
6420344
Tech ID/UC Case 18625/1999-039-0 Related Cases 1999-039-0
美國
