Cartilage Oligomeric Matrix Protein (COMP) is an Aggregator of Growth Factors
Aggregates and presents multiple growth factors Binds to cell surfaces to enhances growth factor activity Allows for localized, longer term delivery of growth factors to cells
Growth-factor/cytokine therapeutics such as wound and muscles healing, post-operative recovery, and preventive therapies Tissue engineering applications Stem cell based therapies
COMP is an essential extracellular matrix protein that forms a “molecular bridge” between extracellular matrix components and provides a structure on which to bind. The modular structure of COMP acts as a scaffold aggregating multiple growth factors and presenting them to the cell surface. In addition to binding multiple TGF-β1 molecules, COMP contains additional binding sites for growth factors and cytokines, including members of the VEGF, FGF, and HGF families.COMP’s cell surface binding properties bring the aggregate complex of COMP and associated growth factors to the cell surface preventing diffusion of the growth factors, increasing the physiological relevance of the signaling, especially where multiple signals are required, and ultimately increasing the growth-related transcription within the cell.
Patent Number: US20130315889A1
Application Number: US13879399A
Inventor: Haudenschild, Dominik | Di Cesare, Paul | Yik, Jasper
Priority Date: 15 Oct 2010
Priority Number: US20130315889A1
Application Date: 12 Aug 2013
Publication Date: 28 Nov 2013
IPC Current: C07K001478 | C07K0014485 | C07K0014495 | C07K001451
US Class: 4240944 | 435375 | 435377 | 5140076 | 5140088 | 5140089 | 5140093 | 530399
Assignee Applicant: The Regents of the University of California
Title: CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP)-GROWTH FACTOR COMPLEXES AND USES THEREOF
Usefulness: CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP)-GROWTH FACTOR COMPLEXES AND USES THEREOF
Summary: For repairing a cartilage lesion which is an articular cartilage lesion or a meniscal cartilage lesion; for promoting bone growth at a bone lesion (i.e. a bone fracture or a spinal fusion site); for promoting chondrogenesis and osteogenesis; and for delivering growth factors to a target cell (i.e. a chondrocyte or an osteoblast) (claimed).
Novelty: New isolated protein complex useful for promoting chondrogenesis and osteogenesis comprises monomers of cartilage oligomeric matrix protein bound to growth factors and has growth factor binding domain
化工/材料
化工/材料應用
9133259
ABSTRACT Researchers at the University of California, Davis have discovered cartilage oligomeric matrix proteins (COMP) can bind and become an aggregate of growth factors. Tech ID/UC Case 22456/2011-089-0 Related Cases 2011-089-0, 2012-227-0
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