Compositions and Methods for Detecting Acetylated Sumo Proteins
A novel non-invasive method to monitor therapeutic response during the course of chemotherapy as well as a novel method for predicting p53 activity in tumorsA valuable research tool to understand tumor biology.Currently there is no known technology or invention which can predict SUMO activity and doing so at the low cost of an antibody is both valuable and practicable.
Monitoring chemotherapy and determining whether chemotherapy is appropriate for cancer patients has been a continuing challenge for physicians. The present invention utilizes antibodies which specifically bind to the acetylation domain small of ubiquitin-like modifier protein (SUMO) as a way to predict therapeutic responses, and therefore to assess whether or not chemotherapy is an appropriate course of action. Since SUMO moieties can either stimulate or inhibit cell proliferation, the present invention also provides a new method for monitoring p53 activity in tumors. The present invention is the first report demonstrating that SUMO is acetylated and that acetylation is important for inducing cell death, particularly during treatment with chemo-therapeutic agents. Thus, levels of acetylation can be used to predict the responsiveness of a tumor to a therapy.
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