Treating Neurodegenerative Disease with Tyrosine Kinase Inhibitors
Potential to rescue cells and halt neurodegenerative death in the brain.Novel approach for the treatment of neurodegenerative disorders.Employs existing FDA approved drugs and this potentially expedites regulatory approval.
Parkin is a key regulator in the clearance and ubiquitination of toxic proteins in neurodegenerative disorders like Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic Lateral Sclerosis (ALS). The present invention identifies novel approach to regulate Parkin for the treatment of neurodegenerative disorders. Georgetown researches show that some commercial drugs regulate parkin and promote clearance and ubiquitination of the toxic proteins that are involved in the neurodegenerative disorders. Thus, the present invention offers a new use of the existing drugs for the treatment of the neurodegenerative disorders.
美國
