A Novel Catalyst System for the Efficient Syntheses of Chiral Alcohols
The chiralligand may be recycled. Provides highyields (>87%) and enantioselectivities (>90%) for a wide range ofsubstrates in various reactions The catalystsystem uses inexpensive alkyl-zinc reagents.
Georgetown University is seeking apartner interested in the commercial application of a novel ligand, catalystsystem. Chiral alcohols represent a fundamental component of many activepharmaceuticals and intermediates. The chiral bisoxazolidine ligand developedat Georgetown is very effective in mediating the syntheses of a variety ofchiral alcohols from aldehydes. Reactions performed with this system employ lowcost alkyl zincs, making this catalyst an atom economical and cost-effectivetool for synthesizing chiral alcohol products and intermediates.
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