Cervical Cancer Screening Using Detection Strips
To help improve cervical cancer screening in LMICs, researchers at Purdue University have developed a simple point-of-care colorimetric test, CERVBIO, for onsite cervical cancer screening and treatment. It is a single-use, user-friendly technology utilizing key protein biomarkers that are sensitive and specific to cervical precancerous lesions. From a previous lateral flow immunochromatography design and employing the use of gold nanoparticles with an enzyme (horseradish peroxidase) as a tracer, this is a highly enhanced, multiplex detection of cancer protein markers within 15 to 30 minutes. It enhances the signal by increasing the number of enzyme molecules around the detection site. In addition, further improvement in the limit of detection can be achieved by increasing the interaction time between the target of interest (cervical cancer antigens) and the antibodies. This innovation is advantageous in that it can detect at picogram levels, is colorimetry-based, easy to use (no need for highly trained personnel), rapid, highly sensitive, quantitative, highly affordable, and can be used independently or integrated into existing platforms, making this beneficial for use in LMICs for the screening of cervical cancer.
User friendly point of care device Fast detection of biomarkers Enhanced detection at low levels
Medical/Health Cervical cancer screening
Joseph IrudayarajPhysiological Sensing FacilityBindley Bioscience CenterPurdue Agricultural & Biological Engineering
United States
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美國
