Creating Chiral Organoalanes and Organic Derivatives
Researchers at Purdue University have developed a method that uses Zr-catalyzed asymmetric carboalumination of alkenes to produce chiral alkylalanes. These chiral alkylalanes can then be converted to various chiral organic compounds, such as isoalkyl alcohols and other organic compounds of interest, which can then be used in the production of vitamins, pharmaceuticals, and other medicinally and biologically important compounds. This process also yields isoalkyl alcohols with a high enantiomeric excess (e.e.), often exceeding 95% e.e.
Can be used in production of various organic compounds of interestYields isoalkyl alcohols with high enantiomeric excess
Chemical AnalysisPhamaceuticalsMedical/Healthcare
Ei-ichi NegishiPurdue Chemistry
United States
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