Accelerated Dissolution Rate of Pharmaceuticals
Researchers at Purdue University have developed a novel approach to overcome the problems of high load, stable solid dispersions. This method, an intimate co-processing of the drug and an excipient, allows smaller-sized particles to dissolve faster while forming a crystalline physical mixture. This procedure enhances the dissolution rate and bioavailability of poorly soluble pharmaceutical compounds, using well-established equipment and methods. The formulated drug exists in a crystalline state, making it thermodynamically stable and far more storable than amorphous formulations. This concept is applicable to many drugs and has already been proven using three different drugs well known for their dissolution-related issues.
Enhances dissolution rate and bioavailability of poorly soluble drugsStorage of crystalline form is far superior Applicable to many drugs and uses well-established equipment and procedures
Medical/HealthcarePharmaceuticalsDrug Development
Rodolfo PinalPinal LabPurdue Industrial and Physical Pharmacy
United States
None
美國
