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Compounds for Cancer Therapy
詳細技術說明
These compounds are potent inhibitors of the isoenzyme PFKFB3,which is over-expressed to enhance glycolysis in most cancer cells. These newlyidentified inhibitors selectively bind to PFKFB3, reduce the Fru-2,6-BP levelsand glycolytic flux, resulting not only in growth inhibition of tumor cells butalso massive cell death. The compoundscan be administered to a patient by any suitable means, including intravenous,parenteral, subcutaneous, intrapulmonary, and intranasal administration.
國家
United States
申請號碼
13/467,764
國家/地區
美國
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