DIAMOnD - DIseAse MOdule Detection Algorithm
The algorithm:ΓÇóIs parameter freeΓÇóStarts with known disease proteins to finally identify disease neighborhood (s) within the networkΓÇóUses a topology of cellular protein interaction networks to rank all the proteins according to their relevance to the diseaseΓÇóIdentifies a local neighborhood within the protein interaction network that is responsible for a diseased phenotypeΓÇóHas been efficiently/successfully tested for identifying and validating asthma disease modulesΓÇóWould be useful for various commercial applications such as:oIdentification of novel drug targetsoIdentification of important gene functionsoIdentification of novel disease pathwaysoIdentification of molecular mechanismsoValidation of repurposed drugsoCreation of individualized disease modules for personal medicineoNon-medical application such as prioritization of nodes in a network
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美國
