Chemo-Hydrothermal Method Increases Biocompatibility and More in Chitosan
Improved water solubility and dispersibility Increased biocompatibility
Antimicrobials Drug delivery Tissue engineering Bioimaging Biosensing Catalysis
This chemo-hydrothermal method is a one-step, one-pot synthesis. When the chitosan and a chemical cross-linker, such as tartaric acid, are cooked together under high pressure, its chemical properties remain unaltered. The chitosan-and-tartaric-acid composites form soluble nanoparticles that are also capable of solubilizing other insoluble materials, such as metal particles and metal oxide particles. When copper is added to this mixture, uniform-sized nanocomposites are formed and the pH level is raised to 7, making the composition neutral.
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