Generation of CTL Lines with Specificity Against Multiple Tumor Antigens
- Multi-TAA CTLs are polyclonal in antigen recognition, polyfunctional for cytokine production, and cytolytic against tumor cells.- Multi-TAA CTLs can be generated from both healthy donors and cancer patients, irrespective of HLA genotype, significantly broaden its potential clinical application.- Besides lymphoma, with different combinations of TTAs, this strategy may be used to target various types of cancers.
Publications:Cytotoxic T lymphocytes simultaneously targeting multiple tumor-associated antigens to treat EBV negative lymphoma. Gerdemann U, Katari U, Christin AS, Cruz CR, Tripic T, Rousseau A, Gottschalk SM, Savoldo B, Vera JF, Heslop HE, Brenner MK, Bollard CM, Rooney CM, Leen AM. Mol Ther. 2011 Dec;19(12):2258-68.
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