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3xSTaA14Q-LT(S63K/R192G/L211A) toxoid fusion for developing antitoxin vaccine against enterotoxigenic Escherichia coli associated diarrhea
技術優勢
A fusion carrying three copies of a STa toxoid to enhance anti-STa immunity, and a triple mutant L T to further eliminate LT enterotoxicity, for safe vaccine development.
詳細技術說明
The invention provides a fusion protein containing 3 copies of a STa mutant protein, as well as a triple mutant LT A1 fragment. This combination creates enhanced immunogenic response to STa as well as reducing the toxicity of the LT toxin. This can be applied to multiple vaccine delivery methods.
國家/地區
美國
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