NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS
The present invention provides nucleic acid aptamers that bind to Plasmodium proteins lactate dehydrogenase and histidine-rich protein II, and uses thereof for the diagnosis of malaria. Aptamers against histidine-rich protein II may be used to detect the presence of Plasmodium species in general, whereas aptamers against lactate dehydrogenase can be used to specifically detect Plasmodium falciparum.
Inventor: TANNER, Julian Alexander | CHEUNG, Yee Wai | KOTAKA, Masayo
Priority Number: WO2013117162A1
IPC Current: C12Q000168 | C07H002104
Assignee Applicant: The University of Hong Kong
Title: NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS | APTAMÈRES D'ACIDE NUCLÉIQUE CONTRE LA LACTICODÉSHYDROGÉNASE DE PLASMODIUM ET LA PROTÉINE II RICHE EN HISTIDINE, ET LEURS
Usefulness: NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS | APTAMÈRES D'ACIDE NUCLÉIQUE CONTRE LA LACTICODÉSHYDROGÉNASE DE PLASMODIUM ET LA PROTÉINE II RICHE EN HISTIDINE, ET LEURS UTILISATIONS POUR LE DIAGNOSTIC DU PALUDISME
Summary: For detecting the presence of Plasmodium in a sample; or determining the formation of the binding complex between the nucleic acid aptamer and Plasmodium lactate dehydrogenase (LDH) or Plasmodium histidine-rich protein II (HRPII) (all claimed); for the diagnosis and treatment of malaria; for detecting Plasmodium falciparum , Plasmodium yoelii , Plasmodium knowlesi , Plasmodium brasilaneum , Plasmodium ovale , Plasmodium chabaudi , Plasmodium vivax , Plasmodium malaria , Plasmodium berghei , Plasmodium reichenowi , and Plasmodium gallinaceum .
Novelty: New aptamer binding to Plasmodium lactate dehydrogenase or Plasmodium histidine rich protein II, comprising a nucleic acid sequence having specific identity to specific nucleic acid sequences for detecting presence of Plasmodium in a sample
生物醫學
病原
13/763,051
美國
