Formulation Of Oral Compositions Comprising Arsenic Trioxide And Methods Of Use Thereof
The Present Invention Provides An Oral Formulation Of Arsenic Trioxide (As2o3) For The Treatment Of A Variety Of Hematological Malignancies, Including Acute Myeloid Leukemia (Aml) And Acute Promyelocytic Leukemia (Apl). The Present Invention Also Provides Methods For Making The Oral Arsenic Trioxide Formulation. Methods Of Using The Oral Arsenic Trioxide Formulation Are Also Described.
Patent Number: AU2003271510A8
Application Number: AU2003271510A
Inventor: KUMANA CYRUS RUSTAM | KWONG YOKLAM
Priority Date: 9 Oct 2002
Priority Number: AU2003271510A8
Application Date: 8 Oct 2003
Publication Date: 4 May 2004
IPC Current: A61K003336 | A61P003502
Assignee Applicant: The University of Hong Kong
Title: Formulation of oral compositions comprising arsenic trioxide and methods of use thereof
Usefulness: Formulation of oral compositions comprising arsenic trioxide and methods of use thereof
Summary: Composition (A) is useful for the treatment of hematological malignancies (preferably acute myeloid leukemia (preferred), acute nonlymphocytic leukemia, myeloblastic leukemia, promyelocytic leukemia, myelomonocytic leukemia, monocytic leukemia, erythroleukemia, myelodysplastic syndrome, acute promyelocytic leukemia (preferred), chronic lymphocytic leukemia, chronic myeloid leukemia, hairy cell leukemia, polycythemia vera, Hodgkin's lymphoma, non-Hodgkin's lymphomas, myeloma, giant cell myeloma, indolent myeloma, localized myeloma, multiple myeloma, plasma cell myeloma, sclerosing myeloma, solitary myeloma, smoldering multiple myeloma, nonsecretary myeloma, osteosclerotic myeloma, plasma cell leukemia, solitary plasmacytoma, and extramedullary plasmacytoma). (all claimed)
Novelty: Preparation of oral composition, useful to treat hematological malignancies, comprises addition of sterile water to arsenic trioxide, followed by subsequent addition of sodium hydroxide and hydrochloric acid to form a solution
診斷/治療
癌症/腫瘤
香港
