Photochemically Crosslinked Collagen Scaffolds And Methods For Their Preparation
A Method For Producing Collagen-Based Scaffolds With Improved Characteristics, Which Broadens The Usage Of Collagen In Tissue Engineering And The Products So Produced Are Described. The Method Comprises Reconstitution Of Three-Dimensional Collagen Matrices From Collagen Monomer Solution And Crosslinking The Matrix With A Light Source In The Presence Of A Photosensitizing Reagent. The Crosslinked Products Can Be In Any Shape And Form And Used In The Dry Or Wet State, For Applications Including But Not Limited To Tissue Engineering And Controlled Drug Delivery.
Patent Number: US7393437B2
Application Number: US2005225108A
Inventor: Chan, Barbara P | So, Kwok Fai
Priority Date: 14 Sep 2004
Priority Number: US7393437B2
Application Date: 14 Sep 2005
Publication Date: 1 Jul 2008
IPC Current: B01J001912 | A61K003839 | C08H000100 | C08H000106
US Class: 20415761 | 20415768 | 424422 | 424456 | 424484 | 530356
Assignee Applicant: The University of Hong Kong
Title: Photochemically crosslinked collagen scaffolds and methods for their preparation
Usefulness: Photochemically crosslinked collagen scaffolds and methods for their preparation
Summary: (M1) is useful for producing a crosslinked collagen and collagen composite scaffold (claimed), where the collagen scaffold is useful for tissue engineering (to repair or replace defective tissues including tendons, ligaments, intervertebral discs, nerves and blood vessels) and controlled drug delivery.
Novelty: Producing crosslinked collagen and collagen composite scaffold, by contacting three-dimensional extracellular collagen matrix with photosensitizing reagent, forming crosslinked scaffold by matrix irradiation, and dehydrating scaffold
生物醫學
生物工程
香港
